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LEAPSynSCI project

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project idea

Late Embryogenesis Abundant Proteins: Structural Characterization and Interaction with α-Synuclein is a project idea to develope a new strategy against amyloid aggregation by employing the constituents of molecular mechanisms underlying the phenomenon of desiccation tolerance: Late Embryogenesis Abundant Proteins which may have role in stabilisation of the correct structure of proteins and cell membranes.

project aims

Producing new recombinant LEAPs

discovering potential of LEAPs originated from the serbian phoenix flower - Ramonda serbica

2020

Conditioning aggregation

of aggregation-prone alpha synuclein and conditioning of the aggregation pathway

2021

Ameliorating the effect

of dehydration-induced damage in liposomes simulating biological membranes

2022

Delivering application

from biotechnology to agriculture (new strategies for crops adaptation to arid climate)

2023

Promising Drug Discovery strategies:

From the ancient resurrection endemic plant to a better medicine

The most common neurodegenerative disorders, Alzheimer’s and Parkinson's diseases are tightly associated with the aggregation of alpha-synuclein into insoluble, amyloid fibrils. Despite numerous contemporary studies focused either on identifying small molecules that could interfere with the alpha-synuclein aggregation or on immunotherapies towards amyloid fibrils, the cure for these diseases has not been found yet. A key objective for discovering the effective treatment is to understand the aggregation pathway of alpha-synuclein and its normal and abnormal functions.

Reduction of the aggregation of α-Synuclein by desiccation-related LEA proteins would promote development of the novel strategies to treat neurodegenerative disorders.

LEAPSyn-Sci is financed by the Science Fund, Republic of Serbia 2019.
Find out more about PROMIS initiative.

project team

profile - marija
Dr. Marija Vidović
Assistant Research Professor
biochemist and plant physiologist
  • Proteomics - metabolomics - MALDI MS imaging and UPLC-ESI-Q/TOF ( method development )
  • Plant abiotic stress
  • Metabolic fluxes
  • UVB induced polyphenols
  • Protein structure / function relationships
profile - jelena
Dr. Jelena Radosavljević
Assistant Professor
biochemist
  • Protein characterization - recombinant protein production - site-directed mutagenesis - proteomics
  • Food protein allergenicity
  • Modifications of food proteins
  • Protein structure / function relationship
profile - sonja
Dr. Sonja Milić Komić
Assistant Research Professor
chemist
  • Antioxidant capacity - EPR - metabolomics
  • Reactive oxygen species
  • Abiotic plant stress
  • Antioxidative activity of amino acids
profile - milena
Dr. Milena G. Rikalović
Assistant Professor - Research Associate
biochemist and microbiologist
  • Applied microbiology - environmental isolates characterisation - fermentations - biotechnology
  • Production of secondary microbial metabolites
  • Microbe – environment interactions
  • Biomarkers
profile - natasa
Dr. Nataša Kilibarda
Assistant Professor
food microbiologist
  • Determination of various microbial species
  • Biotechnology
  • Applied microbiology
  • Fermentations
profile - strahinja
Msc. Strahinja Stevanović
Junior researcher
chemist
  • Proteomics - chemoinformatics - bioinformatics
  • Intrinsically disordered proteins
  • LEA proteins
  • Protein structure / function relationship
profile - sonjav
Dr. Sonja Veljović Jovanović
Research Professor
plant biologist
  • Photosyntesis - antioxidative enzymes - EPR measurements
  • Antioxidant metabolism – effect of biotic and abiotic stresses
  • ROS signalling
  • Resurrection plants
event
master_clnuak
27. 09. 2021.
LEAPSyn-SCI Masters of science !!!

Prošle nedelje naši studenti, Ana Pantelić i Nemanja Marković, su odbranili svoje master teže u okviru našeg LEAPSyn-SCI Promis projekta na hemijskom fakultetu Univerziteta u Beogradu. Eksperimenti su rađeni na #IMGGI i #imsi. Obe teme su za cilj imale rekombinantnu produkciju LEA proteina iz model biljaka Arabidopsis thaliana i Ramonda servis. Protokoli su uspešno optimizovana, a nas čeka finalno prečišćavanje i validacija!🧪⚗️🤞😀

Optimizacija protokola proizvodnje proteina zastupljenog u kasnoj fazi embriogeneze (RsLEA_30) izbiljke vaskrsnice Ramonda serbica tehnikom rekombinantne DNK u bakteriji Escerichia coli. Ana Pantelić. Optimizacija protokola za efikasnu proizvodnju proteina zastupljenog u kasnoj fazi embriogeneze (AtLEA_25) iz biljke Arabidopsis thaliana tehnologijom rekombinantne DNK. Nemanja Marković.

#leapsynsci #fondzanauku #PROMIS #leaproteins #IMGGI #hemijskifakultet #imsi #singidunumuniversity

promotion
rn_s7f6hx
23. 09. 2021.
The first year of our LEAPSyn-SCI

On saturday, september 25th 2021. PROMIS project funded by the Sience Fond of the Repbulic of Serbia, LEAPSyn-SCI managed by Dr. Marija Vidović, will be presented during "Nights of explorers" program at the IMGGE. The project tackles the problem of LEA proteins production from an endemic resurrection plant, Ramonda serbica, and examines their potential to prevent α-synuclein aggregation in order to encourage the development of new therapies in the treatment of Parkinson's disease and similar neurodegenerative diseases based on abnormal peptide / protein aggregation. The project presentation will be held online in the session, starting at 11h. The link for the online presentation is here. Also, subscribe to our channel on youtube to view the other content of the "Nights of explorers" program.

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